B7 Family Proteins in Cancer Progression: Immunological and Non-Immunological Functions

B7-H3 and its relevance in cancer; immunological and non-immunological perspectives.

B7-H3 is a transmembrane glycoprotein and a member of the B7 family of proteins. It was previously known as an immunoregulatory molecule, shown in recent years to be of clinical significance in different types of cancer. In some tumor types high expression of B7-H3 has been linked to a poor prognosis, whereas in other cancers the opposite effect has been observed. Taken together, the precise ro...

Title: Immunological Network Signatures of Cancer Progression and Survival

Progression of cardiac allograft vascular disease as assessed by serial intravascular ultrasound: correlation to immunological and non-immunological risk factors.

OBJECTIVE To characterise the severity and progression of cardiac allograft vascular disease (CAVD) in a large patient cohort, and to evaluate possible immunological and non-immunological risk factors for progression. DESIGN A prospective observational study using intravascular ultrasound. SETTING Two university hospitals. PATIENTS AND MAIN OUTCOME MEASURES Changes in focal plaque, lumen,...

Biological and Immunological Reactions in Parasitic Diseases

Processed antigen reacts selectively with lymphocytes bearing .appropriate surface immunoglobulin molecules resulting in the clonal proliferation of these cells, produc­ing circulating immunoglobulin (humoral immunity) or non-circulating immunoglobulins (cellular immunity).  High levels of circulating immunoglobulins (lgM & lgG) occur in protozoa and helminths infections. Reaginic antibodies a...

Multiple immunological abnormalities in a family.

The family of a woman with multiple autoimmune diseases has been investigated. Clinical evidence of an autoimmune disorder was detected in two relatives, and five others had serological and immunoglobulin abnormalities. It is suggested that there is an inherited predisposition to develop immunological abnormalities, and that a number of associated autoimmune diseases may develop in families in ...